Adapalene acts on retinoid receptors that are commonly found in the skin of face, back and chest. Biochemical and pharmacological studies have demonstrated that Adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of that represent important features in the pathology of acne vulgaris. Adapalene binds with specific retinoic acid nuclear receptors that normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Absorption of Adapalene through human skin is low.
Aclene Cream 0.1% 10 gm
Cream: It should be applied to the affected areas of skin, once daily at night-time
Gel: It should be applied to the entire face and any other affected areas of the skin, once daily in the evening.
A thin film of gel or cream should be applied to the skin areas where lesions present, using enough to cover the entire affected areas lightly