Olopatadine is an inhibitor of the release of histamine from the mast cell and a relatively selective histamine H1?antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells. Olopatadine is devoid of effects on alpha adrenergic, dopamine and muscarinic type 1 and 2 receptors. Following topical ocular administration in human, olopatadine was shown to have low systemic exposure.
Alacot Eye Drop 0.1%
Seasonal allergic rhinitis:
Adult: As 0.6% spray: 2 sprays into each nostril bid.
Child: 6-11 yr 1 spray into each nostril bid.
Adult: As 0.1% soln: 1 drop in the affected eye(s) bid at an interval of 6-8 hr. As 0.2% soln: 1 drop in the affected eye(s) once daily.
Child: ?3 yr Same as adult dose.
Geriatric Use: No overall differences in safety or effectiveness have been observed betweents.