Allylestrenol is a synthetic progesterone derivative that is used to treat threatened pregnancies. It can stop occurring premature labor and can help women give birth to a healthy newborn. It stimulates the secretory phase in myometrium, creates conditions for development of fertilized ovum. It has a tocolytic effect; reduces sensitivity of myometrium to oxytocin. It stimulates the development of acinus of mammary glands, secretory activity of trophoblasts, and development of aldosterone by adrenal glands. Allylestrenol also has a selection of β-adrenergic effect. In this way, it stimulates the synthesis of the body’s placental progesterone, therefore increasing the secretion of placental hormones.
Alestor Tablet 5 mg
Threatened Abortion: 5 mg three times daily for 5-7 days. If necessary, the treatment period may be extended. After disappearance of the symptoms the dosage should be gradually reduced unless symptoms return.
Habitual abortion: 5-10 mg daily as soon as pregnancy has been diagnosed. The administration should be continued until at least one month after the end of the critical period.
Threatened premature labor: The dosage must be determined individually. High dosages (up to 40 mg daily) have been used.