Prazosin competitively blocks postsynaptic α1-adrenoceptors of veins and arterioles causing vasodilation, reduction in BP and total peripheral resistance usually without reflex tachycardia.
Alphapress Tablet 2 mg
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Oral-
Hypertension:
Adult: Initially, 0.5 mg bid or tid for 3-7 days, increased to 1 mg bid or tid for the next 3-7 days, and gradually increased thereafter according to patient’s response. Max: 20 mg/day in divided doses.
Elderly: Dose reduction needed.
Heart failure:
Adult: Initially, 0.5 mg 2-4 times daily gradually increased according to response. Maintenance: 4-20 mg/day in divided doses.
Elderly: Dose reduction needed.
Benign prostatic hyperplasia, Raynaud’s syndrome:
Adult: Initially, 0.5 mg bid, increased to a maintenance dose not exceeding 2 mg bid.
Elderly: Dose reduction needed.