Alurol is used to decrease uric acid concentrations in plasma and/or urine when hyperuricaemia is clinically significant. Alurol and its active metabolite oxypurinol inhibit xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine to uric acid. Inhibition of this enzyme accounts for the major pharmacological effects of Alurol. In contrast with the uricosuric agents that increase the renal excretion of urate, Alurol inhibits the terminal steps in uric acid biosynthesis.
Alurol Tablet 100 mg
Mild gout: 200 to 300 mg/day.
Moderately severe tophaceous gout: 400 to 600 mg/day. The minimal effective dosage is 100 to 200 mg daily and the maximal recommended dosage is 800 mg daily. To reduce the possibility of flare-up of acute gouty attacks, it is recommended that the patient start with a low dose of Allopurinol (100 mg daily) and increase at weekly intervals by 100 mg until a serum uric acid level of 6 mg/day or less is attained but without exceeding the maximal recommended dosage.
Recurrent calcium oxalate stones: 200 to 300 mg/day.
Age 6-10 years: In secondary hyperuricemia associated with malignancies may be given 300 mg Allopurinol daily.
Age under 6 years: generally given 150 mg daily.