Thiopental Sodium for Injection is a thiobarbiturate, the sulfur analogue of Sodium Pentobarbital. The drug is prepared as a sterile powder and after reconstitution with an appropriate diluent is administered by the intravenous route. Thiopental Sodium is an ultra short-acting depressant of the central nervous system, which induces hypnosis and anesthesia, but not analgesia. It produces hypnosis within 30 to 40 seconds of intravenous injection. Recovery after a small dose is rapid, with some somnolence and retrograde amnesia. Repeated intravenous doses lead to prolonged anesthesia because fatty tissues act as reservoir; they accumulate Thiopental Sodium in concentrations 6 to 12 times greater than the plasma concentration, and then release the drug slowly to cause prolonged anesthesia. The half-life of the elimination phase after a single intravenous dose is three to eight hours.
Anestho 1 gm IV Injection
৳ 100.00
Intravenous-
Induction of anaesthesia:
Adult: 100-150 mg of a 2.5 or 5% solution injected over 10-15 sec repeated every 30-60 sec according to response or as a continuous infusion of a 0.2 or 0.4% solution. Max: 500mg. Max in pregnancy: 250mg.
Child: 2-7 mg/kg over 10-15 seconds; repeated after 1 minute if needed..
Elderly: Dose reduction may be needed.
Reduction of raised intracranial pressure:
Adult: Intermittent bolus inj of 1.5-3.5 mg/kg, if adequate ventilation is provided.
Child: 3 mth-15 yr: initial 5-10-mg/kg IV followed by a continuous IV infusion at 1-4 mg/kg/hr.
Elderly: Dose reduction may be needed.
Status epilepticus:
Adult: In conjunction with assisted ventilation: 75-125 mg as a 2.5% solution.
Child: 5 mg/kg by slow IV inj followed by, neonates: continuous iv infusion of 2.5 mg/kg/hr; >1 month: 2-8 mg/kg/hr. Adjust infusion dose according to response.
Elderly: Dose reduction may be needed.