Baclofen is an effective muscle relaxant and antispastic agent with a spinal site of action. It exerts its action by inhibiting both monosynaptic and polysynaptic transmission in the spinal cord by stimulating GABAB receptors.
For Adult: Initially 5 mg three times daily for 3 days; then 10 mg three times daily for 3 days, 15 mg three times daily for 3 days and 20 mg three times daily. Additional increases in dose may be required but should not exceed 20 mg four times daily.
For Children: Initially 0.3 mg/kg/day in 4 divided doses and maintenance dose is 0.75 to 2 mg/kg/day. Titrate to a maximum of 40 mg/day if less than 8 years of age and to a maximum of 60 mg/day if more than 8 years of age.