Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.
Adult: A small quantity of Betamethasone cream or ointment should be applied and rubbed gently to the affected area 2 or 3 times daily until improvement occurs.
Children: Courses should be limited to five days.
Allergic and inflammatory disorders, Congenital adrenal hyperplasia:
Adult: As betamethasone Na phosphate: 0.5-5 mg daily in divided doses, depending on the severity of the disease and clinical response. Recommended regimen: Short-term treatment: 2-3 mg daily for the first few days, then gradually decrease by 0.25 or 0.5 mg every 2-5 days, depending on response. Rheumatoid arthritis: 0.5-2 mg daily. Other conditions: 1.5-5 mg daily for 1-3 wk, then gradually reduce to Min effective dose.
Child: Dose is proportional to adult dose (e.g. 1 yr 25% of adult dose; 7 yr 50% of adult dose; 12 yr75% of adult dose). Treatment is limited to the Min dosage for the shortest possible time.
Eye/Ear/Nasal Drops: Adults and children-
Eye: 1 or 2 drops to each affected eye every 1 or 2 hours until control is achieved, then the frequency may be reduced.
Ear: 2 or 3 drops to each affected ear every 2 or 3 hours until control is achieved, then the frequency may be reduced.
Nose: 2 or 3 drops instilled into each nostril 2 or 3 times daily.