Calcium Folinate is a Calcium salt of Folinic acid (citrovorum factor), is a mixture of the diastereoisomers of the 5-formyl derivative of Tetrahydrofolic acid. It is a metabolite of Folic acid and an essential coenzyme for nucleic acid synthesis used in cytotoxic therapy.
Biofol Tablet 15 mg
Reduction of harmful effects of folic acid antagonists such as. Methotrexate, Trimethoprime etc.: The dose is usually one 15 mg tablet every 6 hours for 2 to 3 days.
Megaloblastic anemia: In the treatment of Megaloblastic anemia, the dose is one 15 mg tablet daily.
Adjunct to fluorouracil in colorectal cancer: 200 mg/m2 BSA by slow IV inj over at least 3 min followed by 370 mg/m2 fluorouracil by IV inj. Treatment is given for 5 consecutive days and repeated at intervals of 28 days for 2 courses. Subsequently, may repeat at 4-5 wkly intervals if the patient has recovered completely from the toxic effects of the prior treatment course.
Folate-deficient megaloblastic anaemia: Up to 1 mg/day.