The active ingredient, Miconazole, is a synthetic imidazole anti-fungal agent with a broad spectrum of activity against pathogenic fungi (including yeast and dermatophytes) and gram-positive bacteria (Staphylococcus and Streptococcus spp). It may act by interfering with the permeability of the fungal cell membranes. When administered orally, Miconazole is incompletely absorbed from the gastrointestinal tract, peak plasma levels of about 1 µg per ml have been achieved after a dose of 1 gm per day. Miconazole is inactivated in the body and 10-20% of an oral dose is excreted in the urine, mainly as metabolites, within 6 days. About 50% of an oral dose may be excreted unchanged in the faeces.
Candoral Oral Gel
For oral administration: Dosage is based on 15 mg/kg/day.
Adults: 1-2 tea-spoonfuls of gel four times daily
Children aged 6 years and over: One tea-spoonful of gel four times daily
Children aged 2-6 years: One tea-spoonful of gel twice daily
Infants under 2 years: Half tea-spoonful of gel twice daily.
For localised lesions of the mouth: A small amount of gel may be applied directly to the affected area with a clean finger. For topical treatment of the oropharynx, the gel should be kept in the mouth for as long as possible. Treatment should be continued for up to 2 days after the symptoms have cleared.
For oral candidasis, dental prostheses: Should be removed at night and brushed with the gel.