Entecavir is a guanosine nucleoside analogue with potent and selective activity against HBV polymerase. For pharmacological action it is phosphorylated to the active triphosphate (TP) form. Entecavir triphosphate functionally inhibits all 3 activities of the viral polymerase-
Priming of the HBV polymerase,
Reverse transcription of the negative strand from the pregenomic messenger RNA
Synthesis of the positive strand HBV DNA.