Dobutamine Hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of cardiac adrenergic receptors; it produces comparatively mild chronotropic, hypertensive, arrhythmogenic and vasodilatory effects. In contrast with dopamine, it does not release norepinephrine and its actions are not dependent on norepinephrine stores in the heart. In humans, Dobutamine Hydrochloride increases stroke volume and cardiac output and decreases ventricular filling pressure and total systemic and pulmonary vascular resistances.
Acute heart failure:
Adult: 2.5-10 mcg/kg/min. Dose range of 0.5-40 mcg/kg/min may be given. Adjust according to patient’s BP, heart rate, cardiac and urine output.
Child: Neonates to 18 yr Initially, 5 mcg/kg/min, adjust to 2-20 mcg/kg/min according to response.
Cardiac stress test:
Adult: 5 mcg/kg/min for 8 min via infusion pump using a soln containing 1 mg/mL. Increase dose by increments of 5 mcg/kg/min up to max 20 mcg/kg/min, w/ each dose being infused for 8 min before the next increase.