Drotaverine is a spasmolytic agent which acts directly on smooth muscle cells by adsorption on the cell surface. Drotaverine inhibits the phosphodiesterase enzyme which leads to an increase of the cAMP level producing smooth muscle cell relaxation. It is thought that Drotaverine also inhibits the initial calcium uptake of the cell. Drotaverine is characterized by a rapid onset of action which is very advantageous in cases of acute painful spastic conditions. Because of its direct action on smooth muscle, Drotaverine does not affect the autonomic nervous system. Therefore Drotaverine is free of the side effects associated with anticholinergic antispasmodics and can be used in glaucoma and prostatic hypertrophy. In addition to its spasmolytic and vasodilatory actions, Drotaverine elicits a selective blockade of cardiac beta receptors.
Drotapan Tablet 40 mg
Adults: 1 to 2 tablets, 3 times daily
Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily.
Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily.
Adults: 1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily.
For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection.