Carvedilol is a non selective ?-adrenergic blocking agent which causes vasodilation by blocking the activity ?-1 receptors. It exerts antihypertensive effect partly by reducing total peripheral resistance and vasodilation.
Hypertension: Initially 12.5 mg once daily, increased after 2 days to usual dose of 25 mg once daily; if necessary may be further increased at intervals of at least 2 weeks to max.50 mg daily in single or divided doses; Elderly: Initial dose of 12.5 mg daily may provide satisfactory control.
Angina: Initially 12.5 mg twice daily, increased after 2 days to 25 mg twice daily.
Heart failure (under special supervision): Initially 3.125 mg twice daily (with food), dose increased at intervals of at least 2 weeks to 6.25 mg twice daily, then to 12.5 mg twice daily, then to 25 mg twice daily, increase to highest dose tolerated, maximum 25 mg twice daily in patients with severe heart failure or body-weight less than 85 kg and 50 mg twice daily in patients over 85 kg.