Permethrin is a synthetic pyrethroid that possesses a broad spectrum of pesticidal activity and low mammal toxicity. It acts on the nerve cell membrane of parasites to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance. Permethrin is rapidly metabolized by ester-hydrolysis to inactive metabolites, which are excreted primarily in the urine.
Elimate Cream 30 gm
Scabies: Apply a thin layer of 5% cream into all skin surfaces from the neck to toes. Wash off after 8-14 hr. 30 g of cream is usually sufficient for an average adult.
Head pediculosis: Apply 30-60 ml of 1% lotion (cream rinse) to washed and towel-dried hair and allow to remain for 10 min. Rinse with water. Treatment may be repeated after 7-10 days if lice or nits are detected in hair-scalp junctions.
Pediculosis pubis: Apply sufficient amount of 1% lotion (cream rinse) or 5% cream to thoroughly saturate the pubic area. Allow to remain for 10 min and then rinse with water.