The fixed-dose combination is recommended for oral administration-
Nausea & vomiting (including morning sickness in pregnancy): One tablet 1-2 times daily.
Motion sickness: One or two tablets one hour prior to journey. The dose may be repeated every 24 hours as indicated for the duration of journey.
Vertigo: One tablet 2 times daily or as directed by physician.
Labyrinthine and vestibular disturbances: The optimal dose of Meclizine Hydrochloride is usually 25 to 100 mg daily in divided doses, depending on the clinical response.
Radiation sickness: 50 mg (Meclizine Hydrochloride) administered 2 to 12 hours prior to radiation treatment. Pyridoxine Hydrochloride (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.
contraceptive pill (ECP) : 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours.
Meclizine has antiemeitic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers.
Pyridoxine Hydrochloride (Vit – B6), either alone or combination has been used to prevent nausea & vomiting due to its antiemetic properties.