Esomeprazole is a PPI that suppresses gastric acid secretion by inhibiting H+/K+ ATPase in the gastric parietal cell. It is the S-isomer of omeprazole.
Emep IV Injection
Esomeprazole is indicated in:
Symptomatic Gastroesophageal Reflux Disease: 20 mg Once daily for 4 weeks
Healing of Erosive Esophagitis: 20 or 40 mg Once daily for 4-8 weeks
Maintenance of Healing of Erosive Esophagitis: 20 mg Once daily
Duodenal Ulcer: 20 mg Once daily for 2-4 weeks
Gastric Ulcer: 20-40 mg Once daily for 8 weeks
H. pylori eradication reduces the risk of duodenal ulcer recurrence: Triple therapy:
Esomeprazole 40 mg: Once daily for 10 days
Amoxycillin 1000 mg Twice daily for 10 days
Clarithromycin 500 mg Twice daily for 10 days
IV Injcetion: The recommended adult dose is either 20 mg or 40 mg Esomeprazole given once daily by intravenous injection (not less than 3 minutes) or intravenous infusion (10 to 30 minutes). Esomeprazole IV injection should not be administered concomitantly with any other medications through the same intravenous site. Treatment with Esomeprazole IV injection should be discontinued as soon as the patient is able to resume treatment with Esomeprazole capsule/tablet. Safety and effectiveness in paediatric patients have not been established.