Erythropoietin (EPO) is a glycoprotein hormone, which is the primary regulator of red blood cell formation in mammals. Recombinant human erythropoietin (r-HuEPO) is a purified glycoprotein, produced from mammalian cells into which the gene coding for human erythropoietin has been inserted.
Epoetin 3000 IU Injection
Treatment of anemia in chronic renal failure:
Erythropoietin is administered to maintain hemoglobin concentration between 11 to 12 g/dl and hematocrit of 33 -36 % in adults.
Adult: usually 50 to 100 IU/kg three times in a week (TIW) by IV or Subcutaneous route
Pediatric: 50 IU/kg TIW by IV or Subcutaneous route
Dose adjustment: Dose should be increased if hematocrit doses not increase by 5 to 6 points after 8 weeks therapy, and hematocrit is below suggested target range. Dose should be reduced when hematocrit approaches 36% or hematocrit increases >4 points in any 2-week period.
Maintenance dose: Maintenance dose must be individualized for each patient. In patients undergoing dialysis, the median maintenance dose is 75 IU/kg TIW, with a range from 12.5 to 525 IU/kg TIW as directed by the physician. In CRF patients not on dialysis, maintenance dose is 75 to 150 IU/kg/week.
Treatment of Anemia in Cancer Patients on Chemotherapy:
Adult: 150 IU/kg TIW by Subcutaneous route or 40,000 IU Subcutaneous route weekly
Pediatric: 25 to 300 IU/kg 3 to 7 times per week by Subcutaneous or IV route
Dose adjustment: If the response is not satisfactory, the dose should be increased to 300 IU/kg TIW. If the hematocrit exceeds 40%, the dose should be withheld until the hematocrit falls to 36%. The dose should be reduced to 25% when treatment is resumed and titrated to maintain the desired hematocrit.
The recommended dose is 300 IU/kg/day subcutaneously for 10 days before surgery, on the day of surgery, and for 4 days after surgery. An alternate dose schedule is 600 IU/kg subcutaneously in once weekly dose (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery.
Zidovudine-treated HIV-infected Patients:
Adult: 100 IU/kg as an IV or Subcutaneous injection TIW for 8 weeks
Pediatric: 50 to 400 IU/kg 2 to 3 times per week by Subcutaneous or IV route
Dose adjustment: If the response is not satisfactory, the dose should be increased by 50-100 IU/kg TIW. Response should be evaluated every 4 to 8 weeks thereafter and the dose adjusted accordingly by 50 to 100 IU/kg increments TIW.
Maintenance dose: The dose is titrated to maintain the hematocrit between 33-36%.
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