Clobetasol has both local anti-inflammatory and immunosuppressive activity. The drug blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin. Clobetasol also reduces the number of human leukocyte antigen & also inhibits phospholipase A2 activity via formation of lipocortin. Clobetasol reduces the formation of prostaglandins and leucotrienes in the local tissues.
Exovate N Cream
Adults and children over 2 years:
Apply sparingly to the affected area once or twice daily until improvement occurs. As with other highly active topical steroid preparations therapy should be discontinued when control is achieved.
In very resistant lesions, especially where there is hyperkeratosis, the anti-inflammatory effect of this preparaton can be enhanced, if necessary, by occluding the treatment area with polythene.
Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient’s condition being reviewed.
Repeated short courses of this preparation may be used to control exacerbations
Elderly: This preparation is suitable for use in the elderly. Caution should be exercised in cases where a decrease in renal function exists and significant systemic absorption of Neomycin Sulphate may occur.
Children: Under 2 years this preparation is not recommended.