Unlike other oestrogens, Estriol is short acting since it has only a short term retention time in the endometrial cells. It substitutes for the loss of estrogen production in menopausal women and alleviates menopausal symptoms.
Estriol is particularly effective in the treatment of urogenital symptoms. In case of atrophy of the lower urogenital tract Estriol induces the normalization of the urogenital epithelium and helps to restore the normal microflora and the physiological pH in the vagina. As a result, it increases the resistance of the urogenital epithelial cells to infection and inflammation reducing vaginal complaints such as dyspareunia, dryness, itching, vaginal and urinary infections, micturition complaints and mild urinary incontinence.