Mefenamic acid, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties with minor anti-inflammatory activity.
Fenamic Oral Suspension
As with other NSAIDs, the lowest dose should be sought for each patient. Therefore, after observing the response to initial therapy with Mefenamic acid, the dose and frequency should be adjusted to suit an individual patient’s needs. Administration is by the oral route, preferably with food.
Adult: A 500 mg dose should be given to adults up to three times (1.5 g total) per day.
Infants over 6 months: 25 mg/kg of body weight daily in divided doses for not longer than 7 days.