Flurium® is the preparation of Flunarizine Hydrochloride, which is the difluorinated derivative of Cinnarizine. Flunarizine, a selective calcium channel blocker prvents cellular calcium overload by reducing excessive transmembrane influxes of calcium without interfering with the normal cellular calcium homeostatis. It has also antihistaminic and sedative properties. Flurium® is indicated in vertigo, motion sickness, migraine, peripheral vascular diseases, alternative hemiplegia of childhood.
Flurium Tablet 10 mg
Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. If, during this treatment depressive, extrapyramidal or other unacceptable symptoms occur, administration should be discontinued. If, after 2 months of this initial treatment, no significant improvement is observed, the patient should be considered a non-responder and administration should be discontinued.
Maintenance Treatment: If a patient is responding satisfactorily and if a maintenance treatment is needed, the dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week. Even if the prophylactic maintenance treatment is successful and well tolerated, it should be interrupted after 6 months and it should be re-initiated only if the patient relapses.
Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required.
Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg).
Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy