Fusidic Acid BP 2% & Hydrocortisone Acetate BP 1% combination cream contains the potent topical antibacterial action of Fusidic Acid with the anti-infammatory & anti-pruritic efects of Hydrocortisone Acetate. When applied topically, Fusidic Acid is efective against Staphylococci, Streptococci, Corynebacteria, Neisseria and certain Clostridia & Bacteroides.
Fusidic Acid is an antimicrobial agent that acts as an inhibitor of protein synthesis in the microorganism. It interferes with translocation step by stabilizing the ribosome-guanosine diphosphate elongation factor G-complex. This prevents binding of aminoacyl t-RNA to the ribosome and thereafter stops transfer of additional amino acids to the growing polypeptide.
In humans, Hydrocortisone is the principal naturally occurring glucocorticosteroid. In pharmaceutical dosage, its main action is to reduce the response of the skin to injury (i.e. anti-infammatory). It also has immunosuppressant & anti-mitotic actions.