Fusidate H cream combines the potent topical antibacterial action of Fusidic Acid with the anti-inflammatory & anti-pruritic effect of Hydrocortisone Acetate. When applied topically, Fusidic Acid is effective against Staphylococci, Streptococci, Corynebacteria, Neisseria and certain Clostridia & Bacteroides.
Fusidic Acid is an antimicrobial agent that acts as an inhibitor of protein synthesis in the microorganism. It interferes with translocation step by stabillizing the ribosome-guanosine di-phosphate elongation factor G-complex. This prevents binding of aminoacyl t-RNA to the ribosom and thereafter stops transfer of additional amino acids to the growing polypeptide.
Hydrocortisone is, in human, the naturally occurring principal glucocorticosteroid. In pharmaceutical doses, its main action is to reduce the response of the skin to injury (i.e. anti-inflammatory). It also has immunosuppressant & anti-mitotic actions.
Fusidate H Cream
Fusidate-H cream should be applied in a thin smear to the rash 2-3 times daily, massaged gently into the skin generally for a period of 7 days to the affected area. As the skin rash improves, the frequency of application should be gradually reduced. As topical steroids exhibit tachyphytaxis, it may be better to omit therapy for several days severy fortnight.