Gaba-P Capsule 50 mg
৳ 12.00
Neuropathic pain: Adult over 18 years: Initially 150 mg daily in 2-3 divided doses, increased if necessary after 3-7 days to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses.
Epilepsy: Adult over 18 years: Initially 25 mg twice daily. Increased at 7-day intervals in steps of 50 mg daily to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses.
Generalised anxiety disorder: Adult over 18 years: Initially 150 mg daily in 2-3 divided doses, increased if necessary at 7-day intervals in steps of 150 mg daily; max. 600 mg daily in 2-3 divided doses.
Fibromyalgia: The recommended dose of Pregabalin is 300-450 mg/day. Dosing should begin at 75 mg twice daily and may be increased to 150 mg two times daily within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg twice daily.
Pregabalin is an analog of the neurotransmitter gamma-aminobutyric acid (GABA). It has analgesic and anticonvulsant activity. Pregabalin binds to an auxiliary subunit (2 protein) of voltage-gated calcium channels in the central nervous system and reduces calcium influx into the nerve terminals. It decreases the release of neurotransmitters such as glutamate, noradrenaline and Substance P. It also increases neural GABA levels by producing a dose dependent increase in Glutamic Acid Decarboxylase (GAD) activity. GAD is the enzyme that converts the excitatory glutamate into inhibitory GABA in a single step. Binding of Pregabalin to the 2 site is required for analgesic and anticonvulsant activity.
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