Gabapentin is an anti-convulsant drug. It is a structural analog of gamma-amino-butyric-acid (GABA). All pharmacological actions following administration of gabapentin are due to the activity of parent compound. It increases brain GABA levels , binds to alpha-2-delta subunit of voltage-gated L-type Calcium channel, and inhibits branched chain amino acid transferase & probably inhibits neurotransmitter release of excitatory amino acids . Food has no effect on the rate and extent of absorption of gabapentin and it is not appreciably metabolized in human. Gabapentin is eliminated from the systemic circulation by renal excretion as unchanged drug. Elimination half-life is 5-7 hours and is unaltered by increased dose or following multiple dosing.
Gabapen Oral Solution
Neuropathic pain: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg daily to maximum 1800 mg daily in three divided doses.
Partial seizure/epilepsy: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg daily to maximum 2400 mg daily in three divided doses.
In case of children:
For 3-12 years: 10 to 15 mg/kg, Incase of titration 25-35 mg/kg daily in 3 divided doses.
Maintenance dose is 900 mg daily (body weight 26-36 Kg) or 1.2 gm daily (body weight 37-50 Kg).