Vildagliptin is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor. It rapidly and completely inhibits DPP-4 activity and thus increases the levels of two incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). Thus it enhances the sensitivity of beta cells to glucose, resulting in improved glucose-dependent insulin secretion. It also enhances the sensitivity of alpha cells to glucose by increasing endogenous GLP-1 levels, resulting in reduced glucagon secretion. The increase in the insulin/glucagon ratio during hyperglycemia due to increased incretin hormone levels results in a decrease in fasting and postprandial hepatic glucose production, leading to reduced glycem
Gluvan Tablet 50 mg
Gluvan can be administered with or without food.
As monotherapy and in dual combination with Metformin, a Thiazolidinedione or Insulin: 50 mg or 100 mg daily. The 50 mg dose should be administered once daily in the morning and the 100 mg dose should be administered as two divided doses of 50 mg in the morning and evening.
In combination with a Sulfonylurea: 50 mg once daily administered in the morning.
Dosage in renal impairment: No dose adjustment is required in patients with mild renal impairment (creatinine clearance >50 ml/min). Not recommended in patients with moderate or severe renal impairment or in hemodialysis patients with end-stage liver disease.
Dosage in hepatic impairment: Should not be used in patients with hepatic impairment.