I-guard contains ChIoramphenicol which is a broad spectrum bacteriostatic antibiotic. It is effective against wide range of Gram-positive and Gram-negative bacteria, cocci and large viruses. ChIorarnphenicol is usually well tolerated and is well penetrated in non-inflammed eye better than any other antibiotic regardless of the mode of administration, resistance is slow to develop, moderate in nature and not necessarily permanent.
I-Guard E/E Drop
For Eye: Adults, children and infants (all age groups): One or two drops 4 to 6 times a day should be placed in the infected eyes. If necessary the frequency of dose can be increased. Treatment should be continued for approximately 7 days but should not be continued for more than three weeks without re-evaluation by the prescribing physician.
For Ear: 2 to 3 drops into ear canal thrice or four times daily.
Otic/Aural: Otitis externa: Instill 2-3 drops of a 5% solution into the ear bid-tid.
Oral: Bacterial meningitis, Anaerobic bacterial infections, Anthrax, Brain abscess, Ehrlichiosis, Gas gangrene, Granuloma inguinale, Infections caused by H. influenzae, Listeriosis, Plague, Psittacosis, Q fever, Severe gastroenteritis, Severe melioidosis, Severe systemic infections with Camphylobacter fetus, Tularaemia, Whipple’s disease:
Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient’s temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever.
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections.