Lactulose is a semi-synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It consists of the monosaccharides fructose and galactose. In the colon, lactulose is broken down primarily to lactic acid, and also to small amounts of formic and acetic acids, by the action of b-galactosidase from colonic bacteria, which results in an increase in osmotic pressure and slight acidification of the colonic contents. This in turn causes an increase in stool water content and softens the stool. In treating hepatic diseases (hepatic encephalopathy), lactulose draws out ammonia from the body in the same way that it draws out water into the colon.
Inolac Concentrated Oral Solution
Adults (including elderly): 3 tea spoonful or 15 ml twice daily
Children 5 to 10 years: 2 tea spoonful or 10 ml twice daily
Children under 5 years: 1 tea spoonful or 5 ml twice daily
Babies under 1 year: ½ tea spoonful or 2.5 ml twice daily (paediatric dose should be given after breakfast)
Each dose of Lactulose may, if necessary, be taken with water or fruit juices, usually once a day, preferably in the morning. If a dose is forgotten it should be taken as soon as one remembers up to 8 hours before bedtime. If later, wait for next scheduled dose (don’t double this dose). Don’t take at bedtime. Usual time lapse before drug works is 30 minutes to 3 hours.