Intamycin injection contains Gentamicin Sulfate USP which is an aminoglycoside antibiotic. Gentamicin is a proven bactericidal antibiotic active against a broad spectrum of Gram-negative pathogens including E. coli, Klebsiella, Proteus spp, Enterobacter, Pseudomonas aeruginosa and Serratia species. It is also active against some Gram-positive organisms (e.g. penicillin & methicillin resistant strains of Staphylococcus aureus). In vitro, Gentamicin is also active against Salmonella and Shigella. Gentamicin interferes with bacterial protein synthesis by binding primarily to the 30S sub-units of bacterial ribosomes in susceptible organisms. Cell death results. Other mechanisms of action may contribute to the bactericidal effect of Gentamicin.
Intamycin 80 Injection
Adult: 3-5 mg/kg 8 hrly for 7-10 days, by IM or slow IV inj over 2-3 min or IV infusion over no more than 20-30 min.
Child: 3-7.5 mg/kg daily in 3 divided doses.
Urinary tract infections:
Adult: 160 mg once daily.
Adult/Child: As 0.1% cream/oint: Apply gently to cleansed affected area 3-4 times daily.
Superficial ophthalmic infections:
Adult/Child: As 0.3% eye drops: Instill 1-2 drops into affected eye up to 6 times daily. For severe infections, initially, 1-2 drops every 15 min, reducing the frequency gradually as the infection is controlled. As 0.3% eye oint: Place a small amount into the conjunctival sac 2-3 times daily.
Adult/Child: As 0.3% ear drops: Instill 2-3 drops in the affected ear 3-4 times a day and at night.