Levofloxacin exerts antibacterial action by inhibiting bacterial topoisomerase IV and DNA gyrase, the enzymes required for DNA replication, transcription repair and recombination. It has in vitro activity against a wide range of gm-ve and gm+ve microorganisms.
Levoxin IV Infusion
Levofloxacin solution for infusion is administered by slow intravenous infusion once or twice daily. The dosage depends on the type and severity of the infection and the sensitivity of the causative pathogen. The duration of treatment varies according to the severity of the disease.
Community-acquired pneumonia: 500 mg once or twice daily,
Complicated urinary tract infections (including pyelonephritis): 250 mg once daily,
Chronic bacterial prostatitis: 500 mg once daily,
Skin and soft tissue infections: 500 mg twice daily
Enteric fever: 500 mg once daily.
Levofloxacin can be used in children aged as low as 6 months. The usual dose for children in community acquired pneumonia is:
Children aged 6 months to less than 5 years: 10 mg/kg b.i.d. (up to 500 mg per day) for 10 days,
Children aged 5 years to 16 years: 10 mg/kg q.d. (up to 500 mg per day) for 10 days.
The usual dose for children in recurrent or persistent Acute Otitis Media is:
Children aged 6 months to less than 5 years: 10 mg/kg per day (maximum dose: 500 mg/day) given twice daily for 10 days.
Paediatric Use: Levofloxacin is not recommended for children less than 6 (six) months of age.