Megatrim® is a broad spectrum antibacterial drug containing Trimethoprim BP and Sulfamethoxazole BP in a 1:5 fixed combination. Megatrim® & Megatrim DS are indicated for Rites, otitis media, Genito-urinary tract infections, GI infections as well as some other infections.
Megatrim Oral Suspension
Acute exacerbations of chronic bronchitis, Acute otitis media, Urinary tract infections:
Adult: 960 mg bid. Severe infections: 2.88 g daily in 2 divided doses.
Child: 6 wk to 5 mth 120 mg bid; 6 mth to 5 yr 240 mg bid; 6-11 yr 480 mg bid.
Pneumocystis (carinii) jirovecii pneumonia:
Adult: 120 mg/kg daily in 2-4 divided doses for 14-21 days.
Child: ≥4 wk Same as adult dose.
Prophylaxis of Pneumocystis(carinii) jirovecii pneumonia:
Adult: 960 mg once daily for 7 days; 960 mg once daily 3 times wkly on alternate days; or 960 mg bid 3 times wkly on alternate days.
Child: ≥4 wk 15-30 mg/kg bid, 2-3 times wkly given on consecutive or alternate days.