Midazolam binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites w/in the CNS, including the limbic system, reticular formation. Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to Cl ions, which results in hyperpolarisation (a less excitable state) and stabilisation. Benzodiazepine receptors and effects appear to be linked to the GABA-A receptors.
Midolam Tablet 7.5 mg
The duration of treatment with oral midazolam should not be more than of 2 weeks. In certain cases extension beyond the maximum treatment period may be necessary.
Adults: 7.5 mg to 15 mg daily (Oral)
Elderly: 7.5 mg daily (Oral)
Premedication: 7.5 mg to 15 mg, should be given 30-60 minutes before the procedure (Oral)
Endoscopic or Cardiovascular procedures:
Adult: initial dose is 2.5 mg (IV)
Elderly & debilitated patients: 1-1.5 mg (IV)
Induction of Anesthesia: Adult: 10-15 mg (IV) or 0.07-0.1 mg/Kg body weight, usually 5 mg (IM)
Children: 0.15-0.20 mg/Kg (IM)
Elderly & debilitated patients: 0.025-0.05 mg/Kg (IM)
Rectal administration in children: for preoperative sedation, rectal administration of the ampoule solution is 0.35-0.45 mg/Kg, 20-30 min before induction of general anesthesia