Migranil Tablet
৳ 3.00
Pizotifen
(in Tablet form)
Dosage:
Adults: The initial adult dose is 1.5 mg daily, this may be taken at bed time as a single dose or in three divided doses. Dosage can be adjusted according to individual patients? requirements up to a maximum of 4.5 mg daily. Up to 3 mg may be given as a single daily dose.
Children: Up to 1.5 mg daily, usually as a divided dose. Use of 1.5 mg at a time is not recommended, but up to 1 mg has been given as a single daily dose at night.
Manufacturer: Opsonin Pharma Ltd.
Pizotifen is a tri-cyclic compound possessing structural similarities to cyproheptadine and tri-cyclic antidepressants.
It inhibits the permeability increasing effect of serotonin and histamine on the affected cranial vessels, thereby checking the transudation of plasmakinin so that the pain threshold of the receptor is maintained at ?normal? levels. In the sequence of events leading to migraine attack, depletion of plasma serotonin contributes to loss of tone of extracranial vessels. Pizotifen inhibits serotonin re-uptake by the platelets, thus maintaining plasma serotonin and preventing the loss of tone and passive diffusion of the extracranial arteries.
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