Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid) belongs to the fenamate group and is a potent inhibitor of cyclo-oxygenase enzyme, thus inhibits the synthesis of important inflammatory mediators such as thromboxane (Tx) B2 and prostaglandin (PG) E2. Prostaglandins are responsible for causing swelling, pain and inflammation associated with these conditions. It acts not only by inhibiting prostaglandin synthesis, but it also has a direct antagonistic action on its receptors.
Migrex 200 Tablet
Acute migraine attacks-
Adult/ Elderly: 200 mg when 1st symptoms appear may be repeated once after 1-2 hr.
Renal impairment: Dose adjustments may be needed. Severe: Avoid.
Mild to moderate pain –
Children: A paediatric dosage regimen has not yet been established.
Adult/ Elderly: 100-200 mg tid.