Misopa® (Misoprostol) is a synthetic prostaglandin E1 analogue that has gastric antisecretory and mucosal protective properties. The antisecretory activity of misoprostol is mediated through a class of high affinity E-type prostaglandin receptors on the surface of gastric parietal cells. Misoprostol achieves cytoprotection by stimulation of gastric mucus secretion, duodenal bicarbonate secretion and gastric mucosal blood flow
Gastric and duodenal ulcers, NSAID-associated ulceration: 800 mcg daily in 2-4 divided doses for at least 4 wk even if symptoms are relieved sooner, may continue up to 8 wk if needed. Further courses may be given if the ulcer relapses.
Prophylaxis of NSAID-induced ulcers: 200 mcg 2-4 times daily; if not tolerated, may reduce dose to 100 mcg 4 times daily.
Gynecological dosage & administration-
Induction of Labor: 25 mcg vaginally 6 hourly or, 50 mcg orally 4 hourly.
Postpartum Hemorrhage (PPH) prophylaxis: 400 mcg to 600 mcg orally or rectally immediately following delivery of the child.
Postpartum Hemorrhage (PPH) treatment: 1,000 mcg rectally or, 200 mcg orally with 400 mcg sublingually
Termination of pregnancy (49 days or less duration): 400 mcg as a single dose, given 36-48 hr after mifepristone.