(Neofloxin) ciprofloxacin has cidal and inhibitory activities against bacteria which result from an interference with DNA gyrase, an enzyme needed by the bacterium for the synthesis of DNA. Thus, vital information from the bacterial chromosomes cannot be transcribed, which causes a break-down of bacterial metabolism.
Ciprofloxacin has a very high in vitro activity against almost all gram negative microorganisms including Pseudomonas aeruginosa. It is also effective against gram positive bacteria, such as Staphylococci and Streptococci. Anaerobes are in general less susceptible.
Topical ocular administration of ciprofloxacin to immature animals did not cause any arthropathy and there is no evidence that the ophthalmic dosage form has any effect on the weight bearing points.
Neofloxin Ophthalmic Solution is indicated for the treatment of different types of eye and ear infections.
Neofloxin E/E Drop 5ML
Corneal Ulcers: The recommended dosage regimen for the treatment of corneal ulcers is two drops into the affected eye every 15 minutes for the first 6 hours and then two drops into the affected eye every 30 minutes for the remainder of the first day. On the second day, instill 2 drops in the affected eye hourly. On the third through the fourteenth day, place two drops in the affected eye every four hours. Treatment may be continued after 14 days if corneal re-epithelization has not been occurred.
Bacterial Conjunctivitis: The recommended dosage regimen for the treatment of bacterial conjunctivitis is one or two drops instilled into the conjunctival sac(s) every two hours while awake for two days and one or two drops every four hours while awake for the next five days.
Ear: For all infections, 2-3 drops every 2-3 hours initially, reducing the frequency of the instillation with control of infection. Treatment should be continued at least 7 days.