Tiotropium is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors, M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3-receptors at the smooth muscle leading to bronchodilation. The bronchodilation following inhalation of Tiotropium is predominantly a site-specific effect.
(in Inhaler form)
Asthma, Chronic obstructive pulmonary disease:
As inhalation cap: 1 cap (18 mcg) daily via inhaler device, at the same time each day.
As inhalation soln: 2 inhalations (5 mcg) daily, at the same time each day.
Manufacturer: Square Pharmaceutical Ltd.