Odeson® is a preparation of USFDA approved 4 mg/ml Dexamethasone Phosphate Injection, 1st time in Bangladesh. It is indicated in cerebral oedema, shock, bronchial asthma, rheumatoid arthritis, severe allergic reactions, inflammatory bowel diseases, certain types of cancer and other inflammatory conditions that require rapid and intense corticosteroid therapy or when treatment by mouth is not possible. Odeson injection may be administered intravenously, intramuscularly, by local injection or as a rectal drip. The injection should be given slowly over a period of several minutes. Intra-articular injections should be given under strictly aseptic conditions.
Inflammatory joint diseases:
Adult: 0.8-4 mg depending on the size of the affected joint. For soft-tissue inj, 2-6 mg may be used. May repeat inj every 3-5 days to every 2-3 wk.
Prophylaxis of nausea and vomiting associated with cytotoxic therapy:
Adult: Prevention: 10-20 mg 15-30 minutes before admin of chemotherapy on each treatment day. For continuous infusion regimen: 10 mg every 12 hr on each treatment day. For midly emetogenic regimen: 4 mg every 4-6 hr.
Adult: As phosphate: Initially, 40 mg or 1-6 mg/kg as a single IV inj, may repeat every 2-6 hr. Continue high-dose treatment only until patient’s condition has stabilised and not to be continued beyond 48-72 hr.
Adult: 0.15 mg/kg 4 times daily, to be given 10-20 min before or with the 1st dose of anti-infective treatment. Treatment should be given for the first 2-4 days of the anti-infective treatment.
Child: As phosphate: 2 mth-18 yr: 150 mcg/kg every 6 hr for 4 days, starting before or with 1st dose of antibacterial treatment.
Cerebral oedema caused by malignancy:
Adult: As phosphate: 10 mg IV followed by 4 mg IM every 6 hr until response is achieved, usually after 12-24 hr. May reduce dosage after 2-4 days then gradually discontinued over 5-7 days. In severe cases, an initial dose of 50 mg IV may be given on day 1, with 8 mg every 2 hr, reduced gradually over 7-13 days. Maintenance dose: 2 mg 2-3 times daily.
Child: As phosphate: 35 kg: Initially 25 mg, then 4 mg every 2 hr for 3 days, then 4 mg every 4 hr for 1 day, then 4 mg every 6 hr for 4 days, then decrease by 2 mg daily. Doses are given via IV inj.