Dexamethasone is a synthetic corticosteroid exhibiting both anti-inflammatory and immuno- suppressant properties. Corticosteroids are hormones produced naturally by the adrenal glands which have many important functions on every organ system.
Odeson Tablet 0.5 mg
Adult: 0.75-9 mg daily in 2-4 divided doses; may also be given via IM/IV admin.
Child: 1 mth-18 yr: 10-100 mcg/kg daily in 1-2 divided doses via oral admin, adjusted according to response; up to 300 micrograms/kg daily may be used in emergency situations.
Screening test for Cushing’s syndrome:
Adult: 0.5 mg every 6 hr for 48 hr after determining baseline 24-hr urinary 17-hydroxycorticosteroid (17-OHCS) concentrations. During the second 24 hr of dexamethasone admin, urine is collected and analysed for 17-OHCS. Alternatively, after a baseline plasma cortisol determination, 1 mg may be given at 11 pm and plasma cortisol determined at 8 am the next morning. Plasma cortisol and urinary output of 17-OHCS are depressed after dexamethasone admin in normal individuals but remain at basal levels in patients with Cushing’s syndrome.
Acute exacerbations in multiple sclerosis:
Adult: 30 mg daily for 1 wk followed by 4-12 mg daily for 1 mth.
Child: 1 mth-12 yr: 100-400 mcg/kg daily in 1-2 divided doses; 12-18 yr: Initially 0.5-24 mg daily. Max. 24 mg daily.