It is a combination of an angiotensin II receptor antagonist (AT1 subtype), Olmesartan Medoxomil, and a thiazide diuretic, hydrochlorothiazide (HCTZ). Olmesartan Medoxomil, a prodrug, is hydrolyzed to Olmesartan during absorption from the gastrointestinal tract.
Olmesan Plus Tablet
The usual recommended starting dose of Olmesartan Medoxomil is 20 mg once daily when used as monotherapy in patients who are not volume-contracted. For patients requiring further reduction in blood pressure after 2 weeks of therapy, the dose may be increased to 40 mg. No initial dosage adjustment is recommended for elderly patients, for patients with moderate to marked renal impairment (creatinine clearancedysfunction.
Hydrochlorothiazide is effective in doses between 12.5 mg and 50 mg once daily.