Omastin® (Fluconazole) is a triazole antifungal agent. It is a potent and selective inhibitor of fungal cytochrome P-450 dependent enzymes necessary for the synthesis of ergosterol.The daily dose of Omastin® should be based on the nature and severity of the fungal infection. Treatment should be continued until clinical parameters or laboratory tests indicate that active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection. Immuno compromised patients.
Omastin 200mg Capsule
Oropharyngeal Candidiasis: 200 mg on the first day, followed by 100 mg once daily for 7-14 days.
Esophageal Candidiasis: 200 mg on the first day, followed by 100 mg once daily for 2-3 weeks.
Systemic Candidiasis and Cryptococcal Meningitis: 400 mg daily followed by 200 mg once daily. The recommended duration of treatment for initial therapy of cryptococcal meningitis is 10 to 12 weeks.
Acute or recurrent vaginal candidiasis: Single dose of 150 mg.
Urinary Tract Infections and Peritonitis: 50 to 200 mg once daily. Prophylaxis in Patients Undergoing Bone Marrow Transplantation: 400 mg once daily.
Oropharyngeal Candidiasis: 6 mg/kg on the first day, followed by 3 mg/kg once daily. Treatment should be administered for at least 2 weeks to decrease the likelihood of relapse.
Esophageal Candidiasis: 6 mg/kg on the first day, followed by 3 mg/kg once daily.
Cryptococcal meningitis: Initial therapy should be started with 6 to 12 mg/kg daily. Doses up to 12 mg/kg/day may be used for three weeks and treatment for initial therapy of cryptococcal meningitis is 10 to 12 weeks.