Nausea and Vomiting is usually produced by chemotherapeutic agents by releasing serotonin from the enterochromaffin cells of the small intestine.The released serotonin (5-HT) then activates 5-HT3 receptors located on vagal afferents to initiate the vomiting reflex. Postoperative nausea and vomiting is influenced by multiple patient, surgical and anesthesia related factors and is triggered by release of serotonin (5-HT) in a cascade of neuronal events involving both the central nervous system and the gastrointestinal tract. The 5-HT3 receptor has been demonstrated to selectively participate in the emetic response. Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and little or no affinity for other receptors. So by binding with this receptor palonosetron inhibits binding of serotonine to this receptor and also inhibits vomiting reflux.
Paloset IV Injection
(in Tablet form)
Chemotherapy-Induced Nausea and Vomiting Palonosetron 0.25 IV Injection-
Adults: A single 0.25 mg I.V.dose administered over 30 seconds approximately 30 minutes before the start of chemotherapy.
Children (From 1 month to 17years): 20 mcg/Kg I.V.dose administered over 15 minutes approximately 30 minutes before the start of chemotherapy.
Postoperative Nausea and Vomiting Palonosetron 0.075 IV Injection-
Adults: A single 0.075 mg I.V. dose administered over 10 seconds immediately before the induction of anesthesia.
Children (From 1 month to 17years):Not recomended.
Palonosetron Tablet- A single tablet should be used only on the day of chemotherapy. If symptoms persist, can be used once in a days or once every two days for three doses on consecutive days.
Manufacturer: Square Pharmaceutical Ltd.