Clopidogrel is an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. Clopidogrel also inhibits platelet aggregation induced by agonists other than ADP by blocking the amplification of platelet activation by released A.P. Clopidogrel does not inhibit phosphodiesterase activity.
Plagrin Tablet 75 mg
Prevention of artherosclerotic events in peripheral arterial disease or after myocardial infarction or ischaemic stroke: 75 mg once daily.
Acute coronary syndrome (without ST-segment elevation): initially 300 mg then 75 mg daily.
Acute myocardial infarction (with ST-segment elevation): initially 300 mg then 75 mg daily; initial dose omitted if patient over 75 years.