Prosan® (Losartan Potassium) is an angiotensin-II receptor (type AT1) antagonist. Angiotensin-II is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone secreting effects of angiotensin-II by selectively blocking the binding of angiotensin-II to the AT1 receptor found in many tissues. It is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
Prosan Tablet 50 mg
The usual starting and maintenance dose is 50 mg once daily for most patients. The maximal antihypertensive effect is attained 3-6 weeks after initiation of therapy. Some patients may receive an additional benefit by increasing the dose to 100 mg once daily. In patients who are salt depleted corrective measures should be used before starting Losartan and the initial dose should be reduced to 25 mg. Losartan may be administered with other antihypertensive agents. Losartan may be administered with or without food.
No initial dosage adjustment is necessary in patients with mild renal impairment (CrCl 20-50 ml/min). For patients with moderate to severe renal impairment (CrCl < 20 ml/min) or patients on dialysis, a lower starting dose of 25 mg is recommended. Use in elderly: Patients up to 75 years: No initial dosage adjustment is necessary for this group of patients. Patients over 75 years: A lower starting dose of 25 mg once daily is recommended.