Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It is assumed that it works by reducing lung fibrosis through down regulation of the production of growth factors and pro-collagen.
Recommended dosage: The recommended daily maintenance dosage of pirfenidone is
801 mg (three capsules) three times daily taken with food. Doses should be taken at the
same time each day.
Upon initiation of treatment, the daily dosage should be titrated to the full dosage of nine capsules per day over a 14-day period as follows:
Day 1 through 7: 1 Capsule 3 times a day with meals
Day 8 through 14: 2 Capsule 3 times a day with meals
Day 15 onwards : 3 Capsule 3 times a day with meals
Dosages above 2403 mg/day (9 capsules per day) are not recommended for any patient.
Patients who miss 14 or more days of pirfenidone should be re-initiate treatment by undergoing the initial 2 week titration regimen up to full maintenance dosage. For the treatment interruption of less than 14 days, the dosage prior to the interruption can be resumed.