Clarithromycin is a macrolide antibiotic, Amoxycillin is a broad spectrum penicillin preparation & Rabeprazole is a proton pump inhibitor. Clarithromycin shows bactericidal activity by inhibiting protein synthesis of H. pylori. Amoxycillin destroys cell wall of H. pylori & has got bactericidal effect. Rabeprazole inhibits proton pump of parietal cells & decrease hyperacidity. Moreover it heals peptic ulcer.