Clindamycin inhibits protein synthesis by reversibly binding to the 50S ribosomal subunit, thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting to stunted cell growth.
It has activity against-
Aerobic gram-positive cocci, including: Staphylococcus aureus, Staphylococcus epidermidis (penicillinase and non-penicillinase producing strains), Streptococci, Pneumococci.
Anaerobic gram-negative bacilli including: Bacteroides species, Fusobacterium species.
Anaerobic gram-positive non-spore forming bacilli including:
Propionibacterium species, Eubacterium species, Actinomyces species.
Anaerobic and microaerophilic gram-positive cocci including: Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci, C. perferinges.