Ranolazine has anti-ischemic and anti-angina effects that do not depend upon reduction in heart rate or blood pressure. It does not affect the rate-pressure product, a measure of myocardial work, at maximal exercise. Ranolazine at therapeutic levels can inhibit the cardiac late sodium current (INa). Thereby it causes decreased influx of Ca++ through Na+-Ca++ channel. Thus, it inhibits Ca++ overload and decreases oxygen consumption of heart.
Ralozine 500 SR Tablet
Initiate Ranolazine dosing at 500 mg twice daily and increase to 1000 mg twice daily, if needed, based on clinical symptoms. Take Ranolazine with or without meals. Swallow Ranolazine tablets whole; do not crush, break or chew. The maximum recommended daily dose of Ranolazi