Retapamulin is a semisynthetic derivative of the compound pleuromutilin. In vitro activity of Retapamulin against isolates of Staphylococcus aureus as well as Streptococcus pyogenes has been demonstrated. Retapamulin selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that is different from that of other antibiotics.This binding site involves ribosomal protein L3 and is in the region of the ribosomal P-site and peptidyl transferase center. By virtue of binding to this site, pleuromutilins inhibit peptidyl transfer, block P-site interactions and prevent the normal formation of active 50S ribosomal subunits. Retapamulin demonstrates no in vitro target-specific cross-resistance with other classes of antibiotics.
Retapex Ointment 10 gm
Retapamulin is indicated for use in adults and pediatric patients (aged 9 months and older) for the topical treatment of following skin infections due to Staphylococcus aureus or Streptococcus pyogenes.
Secondary skin infections: Infected dermatitis, infected traumatic lesions (e.g. small lacerations, sutured wounds, cuts, abrasions etc.)